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March 1989

Increased Serum Interleukin 2 Receptor Concentration in Schizophrenic and Brain-Damaged Subjects

Author Affiliations

Departments of Psychiatry and Pathology School of Medicine University of Pittsburgh Pittsburgh, PA 15261

Arch Gen Psychiatry. 1989;46(3):292. doi:10.1001/archpsyc.1989.01810030098018

To the Editor.—  It has been suggested that autoimmunity may play a role in the pathogenesis of symptoms in some schizophrenics.1,2 Activation of the immune system by an ongoing autoimmune disease is associated with measurable alterations in T-lymphocyte function. In patients with an autoimmune disease, T lymphocytes have a decreased response to nonspecific mitogenic stimulation and produce reduced amounts of interleukin 2 (IL-2).3-5 As IL-2 is necessary for T lymphocytes to respond in a normal manner to nonspecific mitogens, the reduced mitogenic activity may reflect low IL-2 production by the T cells.Recently it has been suggested that the low lymphocyte production of IL-2 in patients with an autoimmune disease occurs because the T cells are activated and the lymphocyte-derived IL-2 has been released into the serum.6 Alternatively, the IL-2 released from lymphocytes may be bound by soluble IL-2 receptor (IL-2R) released from the cell surface. If

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