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Article
April 1989

Outpatient Treatment of 'Crack' Cocaine Smoking With Flupenthixol DecanoateA Preliminary Report

Author Affiliations

From the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn (Dr Gawin); and The Princess Margaret Hospital (Dr Allen) and The Sandilands Hospital (Dr Humblestone), Nassau, Bahamas.

Arch Gen Psychiatry. 1989;46(4):322-325. doi:10.1001/archpsyc.1989.01810040028005
Abstract

• "Crack" cocaine abuse often produces severe cocaine dependence that is refractory to available pharmacological and outpatient psychotherapeutic treatments. We conducted two preliminary investigations evaluating the efficacy of flupenthixol decanoate, a depot xanthene requiring infrequent intramuscular administration, in the treatment of cocaine withdrawal. Ten outpatient crack cocaine smokers with poor prognoses were administered flupenthixol decanoate in an open-label, open-ended trial. Flupenthixol decanoate was well tolerated and appeared to decrease cocaine craving and use markedly and rapidly, producing a 260% increase in the average time retained in treatment among these subjects. These promising but preliminary data, combined with the magnitude of problems presented by crack, warrant rapid, expanded double-blind assessment of flupenthixol decanoate in cocaine-abuse treatment.

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