• While some advances have occurred in the maintenance treatment of unipolar depression, empirical data on recurrences of illness following the discontinuation of medication are sparse. We examined survival time during the first 18 months after discontinuation of medication in 74 patients with recurrent unipolar depression. Although demographic characteristics, clinical characteristics, and pharmacologic treatment variables failed to predict time to recurrence, continued interpersonal psychotherapy was significantly related to longer survival time.
Frank E, Kupfer DJ, Perel JM. Early Recurrence in Unipolar Depression. Arch Gen Psychiatry. 1989;46(5):397-400. doi:10.1001/archpsyc.1989.01810050011002