July 1989

The 'Efficacy' of Alprazolam in Panic Disorder and Agoraphobia: A Critique of Recent Reports-Reply

Author Affiliations

Department of Psychiatry Cornell University Medical College New York, NY
Department of Psychiatry and Behavioral Sciences Medical University of South Carolina 171 Asley Ave Charleston, SC 29425
Department of Psychiatry University of Melbourne Melbourne, Australia
DuPont Associates, P.A.
Department of Psychiatry 500 Newton Rd University of Iowa College of Medicine Iowa City, IA 52242
Department of Psychiatry Douglas Hospital 6875 Boulevard LaSalle Westmount, Quebec Canada H4H 1R3
Department of Psychiatry The Mount Sinai School of Medicine Elmhurst, NY
Division of Biological Psychiatry Harbor/UCLA Medical Center Torrance, CA
Department of Psychiatry Toronto General Hospital Toronto, Ontario Canada

Arch Gen Psychiatry. 1989;46(7):670-672. doi:10.1001/archpsyc.1989.01810070096016

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In Reply.—  Professor Marks and a number of distinguished psychiatrists and psychologists from several countries have written to criticize the set of our articles reporting on the first phase of the Cross-National Collaborative Panic Study, which appeared in the May 1988 issue of the Archives. Their letter raises a number of questions specific to the study's findings and comments on larger issues in the treatment of panic disorder and agoraphobia.

Establishing the Short-term Efficacy of Alprazolam for Panic Disorder and Agoraphobia.—  The main criticism of Professor Marks and associates' is that "this claim of 'efficacy' is misleading given the arguable interpretation of the data presented." To respond to this criticism, it is important to specify the criteria of efficacy being employed. Nowhere in the letter from Professor Marks et al do they state explicitly their criteria for efficacy.In the Cross-National Collaborative Panic Study, First Phase, the criteria of

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