• The interaction between anxiety disorder and major depressive disorder in patients with cerebrovascular lesions was examined in a controlled, 2×2 study design. A consecutive series of 24 patients who met criteria for major depression only were compared with 6 patients who met criteria for generalized anxiety disorder only, 23 patients who met criteria for both major depression and generalized anxiety disorder, and 45 patients who did not meet criteria for either major depression or generalized anxiety. Among patients with positive computed tomographic scans, the anxious-depressed group (n = 19) showed a significantly higher frequency of cortical lesions, while patients with major depression only (n = 15) had a significantly higher frequency of subcortical (basal ganglia) strokes. No significant betweengroup differences were found in other variables, such as demographic variables, familial and personal history of psychiatric disorders, and neurologic deficits. These findings suggest that, in this mostly black, low-socioeconomic-status population, cortical vs subcortical lesion location may play an important role in determining whether severe anxiety occurs in patients with poststroke major depression.
Starkstein SE, Cohen BS, Fedoroff P, Parikh RM, Price TR, Robinson RG. Relationship Between Anxiety Disorders and Depressive Disorders in Patients With Cerebrovascular Injury. Arch Gen Psychiatry. 1990;47(3):246-251. doi:10.1001/archpsyc.1990.01810150046008