November 1990

Pronounced Reduction of Total Neuron Number in Mediodorsal Thalamic Nucleus and Nucleus Accumbens in Schizophrenics

Author Affiliations

From the Neurological Research Laboratory, Hvidovre Hospital, Copenhagen, Denmark.

Arch Gen Psychiatry. 1990;47(11):1023-1028. doi:10.1001/archpsyc.1990.01810230039007

• Using a new and unbiased stereological technique, the total numbers of neuron and glial cells in the mediodorsal thalamic nucleus and the nucleus accumbens were found to be significantly reduced in schizophrenic patients compared with controls. The total neuron and glial cell number in the ventral pallidum and in the basolateral nucleus of amygdala did not differ in the two groups.