February 1991

Dosage of Haloperidol for Schizophrenia

Author Affiliations

From the Departments of Psychiatry, Long Island Jewish Medical Center, at Queens Hospital Center Affiliation, Jamaica, NY (Drs Rifkin, Doddi, and Karajgi), and at Hillside Hospital, Glen Oaks, NY (Dr Borenstein). Dr Wachspress was formerly with the Department of Psychiatry, Elmhurst (NY) Hospital Center Affiliation of the Mount Sinai Medical Center; he is retired.

Arch Gen Psychiatry. 1991;48(2):166-170. doi:10.1001/archpsyc.1991.01810260074011

• Eighty-seven newly admitted inpatients with schizophrenia were randomized to receive 10, 30, or 80 mg/d of oral haloperidol. They were treated under double-blind conditions for 6 weeks, less if their acute symptoms remitted sooner. Survival analysis showed no differences among the three treatments. Side effects were minimal in all three treatment groups, and there were no differences in side effects among the groups. These results suggest that dosages higher than 10 mg/d of haloperidol for most patients have no additional beneficial effect in the treatment of acute or exacerbated schizophrenia.