February 1991

Cerebral Size Affects Localized Density Measured by Computed Tomography

Author Affiliations

Laboratory of Psychology and Psychopathology
Laboratory of Clinical Science National Institute of Mental Health 9900 Rockville Pike Bethesda, MD 20892
Center for Neuropsychology 200 Newport Center Dr, Suite 205 Newport Beach, CA 92660
5920 Searl Terr Bethesda, MD 20816
Psychobiology Research Unit Department of Psychology Tel Aviv University 69978 Tel Aviv, Israel

Arch Gen Psychiatry. 1991;48(2):178-179. doi:10.1001/archpsyc.1991.01810260086013

To the Editor.—  Pearlson et al,1 in the August 1989 issue of the Archives, reported that larger overall brain area was associated with lower computed tomographic density in schizophrenic and control individuals, replicating a similar finding by Jernigan et al.2 We herein report3 that this inverse correlation holds true for certain, but not all, cerebral regions of interest (ROIs). We conclude that studies attempting to associate behavior with cerebral density should control for this sizedensity relationship.

Patients and Methods.—  Fifty-six psychiatrically screened subjects with clinically normal computed tomographic (CT) scans were included in this study. Age ranged from 18 to 73 years, with 31 men and 25 women. Scans were performed on a GE 8800 scanner (General Electric Medical Systems, Milwaukee, Wis), and ROI measurements were performed independently on two separate occasions by a radiologist. Regions of interest included both left and right frontal gray, frontal

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