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March 1991

Neurologic Soft Signs in Obsessive-Compulsive Disorder

Author Affiliations

Laboratory of Clinical Science National Institute of Mental Health NIH Clinical Center 10/3 D41 Bethesda, MD 20892

Arch Gen Psychiatry. 1991;48(3):278. doi:10.1001/archpsyc.1991.01810270090013

To the Editor.—  Hollander and coworkers1 reported some illuminating findings of increased neurologic soft signs in medication-free patients with obsessive-compulsive disorder (OCD). They noted that these findings were preliminary and that further study of patients with OCD as well as comparisons with other groups of psychiatric patients were warranted. We recently evaluated 39 patients with OCD and comparison groups of patients with non-OCD anxiety disorders (n = 10) and seasonal affective disorder (SAD) (n = 13), as well as 43 healthy volunteers. Traditionally, patients are studied for soft signs in a medication-free state; however, we felt that it might be interesting to also look at the effect of medication on soft signs. Thus, the 39 patients with OCD included 14 who were medication free, 13 who were receiving clomipramine (75 to 250 mg/d), and 12 who were receiving fluoxetine (40 to 80 mg/d) for a minimum of 8 weeks. The healthy

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