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October 1991

Evidence of Reduced Temporolimbic Structure Volumes in Schizophrenia-Reply

Author Affiliations

Department of Neurology Harvard Medical School Beth Israel Hospital 330 Brookline Ave Boston, MA 02215
Wurzburg, Germany

Arch Gen Psychiatry. 1991;48(10):957-958. doi:10.1001/archpsyc.1991.01810340089013

The 1985 article by Dr

Bogerts et al1 is an important contribution to the neuropathology of schizophrenia. They interpreted their findings as evidence for structural changes in at least a subgroup of schizophrenic subjects "if corroborated by studies of larger and sexmatched groups." Dr Bogerts et al take issue with our study,2 which was larger, compared groups matched for sex and age, and could not replicate his postmortem findings. We consider four issues as important.

1. Indeed, our study is in contrast to other postmortem and in vivo studies. Of these, 14 of the 15 studies have been positive and ours was negative; this ratio appears to be conclusive. However, a closer look at the neuroimaging literature reveals that there are at least three more studies that did not find any differences in limbic structures of the medial temporal lobe comparing schizophrenic subjects with controls.3,4,5 Furthermore, positive

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