January 1992

Cerebrospinal Fluid Neurochemistry in Children and Adolescents With Obsessive-Compulsive Disorder

Author Affiliations

From the Child Psychiatry Branch (Drs Swedo, Leonard, Kruesi, and Rapoport, Mr Rettew, and Ms Hamburger), the Biological Psychiatry Branch (Mr Listwak and Dr Gold), the Clinical Neurogenics Branch (Dr Berrettini), and the Section on Clinical Pharmacology, Laboratory of Clinical Science (Mr Stipetic and Dr Potter), National Institute of Mental Health, Bethesda, Md.

Arch Gen Psychiatry. 1992;49(1):29-36. doi:10.1001/archpsyc.1992.01820010029004

• Cerebrospinal fluid hormones, monoaminergic metabolites, and dynorphin A (1-8 sequence) were examined in 43 children with severe, primary obsessive-compulsive disorder. Cerebrospinal fluid levels of 5-hydroxyindoleacetic acid were positively correlated with one of eight obsessivecompulsive disorder severity ratings and three of seven measures of improvement following 5 weeks of treatment with clomipramine hydrochloride. Arginine vasopressin concentration was significantly and negatively correlated with several ratings of obsessive-compulsive disorder symptom severity, while oxytocin concentration was positively correlated with depressive symptoms. The ratio of arginine vasopressin to oxytocin was also negatively correlated with obsessive-compulsive disorder and depressive symptoms. Comorbid affective disorder was associated with decreased arginine vasopressin concentrations, while concomitant anxiety disorder was associated with increased oxytocin. Dynorphin A (1-8 sequence), homovanillic acid, corticotropin, 3-methoxy-4-hydroxyphenylglycol, and corticotropin releasing hormone were not significantly related to obsessive-compulsive disorder symptoms. These results seem to indicate that arginine vasopressin may be related to obsessive-compulsive disorder symptom severity, while 5-hydroxyindoleacetic acid might be associated with drug response.