• Canine acral lick dermatitis is a naturally occurring disorder in which excessive licking of paws or flank can produce ulcers and infection that require medical treatment. Fortytwo dogs with severe chronic canine acral lick dermatitis were treated in three double-blind crossover comparisons of clomipramine hydrochloride/desipramine hydrochloride, fluoxetine hydrochloride/fenfluramine hydrochloride, and sertraline hydrochloride/placebo. The serotonin uptake blocking drugs were clinically effective, while the other drugs were not. Based on phenomenology and pharmacological response, we propose canine acral lick dermatitis as an animal model of obsessive-compulsive disorder.
Rapoport JL, Ryland DH, Kriete M. Drug Treatment of Canine Acral LickAn Animal Model of Obsessive-compulsive Disorder. Arch Gen Psychiatry. 1992;49(7):517-521. doi:10.1001/archpsyc.1992.01820070011002