The report by Rubin et al1 on single-photon emission computed tomography (SPECT) of regional cerebral blood flow in patients with obsessive-compulsive disorder (OCD) referred to our previous article.2 They noted that ours was the only other patient-control SPECT study of OCD to date. We reported increased "medial-frontal" cortical blood flow in patients with OCD compared with controls, but no difference in "orbital-frontal" flow as defined previously by Baxter et al.3,4 Rubin et al concluded that they had found increased orbital-frontal perfusion in their group of patients with OCD.
However, a comparison of the regions defined as orbital-frontal in their group and medial-frontal in our study shows that these regions differ more in name than in anatomical location, and that both are different from the orbital-frontal regions defined by Baxter et al.3,4 Both the medial-frontal region in our study and the orbital-frontal region in the study by
Harris GJ, Pearlson GD, Hoehn-Saric R. Single Photon Emission Computed Tomography in Obsessive-Compulsive Disorder. Arch Gen Psychiatry. 1993;50(6):498–499. doi:10.1001/archpsyc.1993.01820180100015