October 1993

Strong Inference, Theory Testing, and the Neuroanatomy of Schizophrenia

Author Affiliations

From the Maryland Psychiatric Research Center, Baltimore (Drs Carpenter, Buchanan, Kirkpatrick, and Tamminga); and Bowman Gray School of Medicine, Winston-Salem, NC (Dr Wood).

Arch Gen Psychiatry. 1993;50(10):825-831. doi:10.1001/archpsyc.1993.01820220081009

Failure to address the putative etiologic and pathophysiologic heterogeneity of the schizophrenia syndrome and problems in definitive assessment of human brain function have impaired progress in schizophrenia research. New approaches to psychopathology and converging evidence from antemortem and postmortem study can now result in more decisive study of the neuroanatomy and neuropathology of schizophrenia.