October 1996

TPH Replication Study: Not!

Author Affiliations

Laboratory of Neurogenetics Division of Intramural Clinical and Biological Research National Institute on Alcohol Abuse and Alcoholism Flow Building, Room 2 12501 Washington Ave Rockville, MD 20852
Bethesda, Md

Arch Gen Psychiatry. 1996;53(10):964-965. doi:10.1001/archpsyc.1996.01830100114015

WE reported a population association between a tryptophan hydroxylase (TPH) intron 7 polymorphism with suicidal behavior in Finnish alcoholic offenders and with cerebral spinal fluid 5-hydroxyindoleacetic acid concentration in impulsive offenders.1 Abbar et al2 found no association between a different TPH polymorphism and suicidal behavior in a clinically and ethnically divergent sample. Our TPH association was presented as a preliminary result requiring replication. However, the study by Abbar et al2 has little relevance to the validity of the association we observed. They used a different, unpublished TPH marker to genotype both women and men who were undergoing psychiatric care and who had a dissimilar and mixed diagnostic profile and a different ethnic background. Therefore, the assertion by Abbar et al of a "discrepancy" between their and our results has no basis.

The Ava II restriction fragment length poIymorphism used by Abbar et al2 is distinct from

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