December 1996

The Relationship Between Plasma Haloperidol Concentrations and Clinical Results

Author Affiliations

Centre de Salut Mental-Hospital General de Mollet Cristobal Colón, 1 08100-Mollet Barcelona Spain
Barcelona, Spain

Arch Gen Psychiatry. 1996;53(12):1167-1168. doi:10.1001/archpsyc.1996.01830120107019

The article by Volavka et al1 in the October 1995 issue of the Archives supports the existence of an upper limit of haloperidol plasma concentrations of approximately 12 ng/mL for the treatment of patients with acutely exacerbated schizophrenia.

Volavka et al1 do not report a clear lower limit for the antipsychotic activity of plasma concentrations of haloperidol. The authors suggest that a "continuous increase of antipsychotic activity from levels close to 0 to approximately 12 ng/mL" exists.1 However, the definition of a minimum haloperidol plasma concentration for a meaningfulantipsychotic effect may have clinical relevance. The reanalysis of their data using the lower limit found in our study2 showed that while only 54.8% of the patients with plasma concentrations less than 5.5 ng/mL were considered improved, the value for patients with concentra

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