Hoffman and McGlashan are generally accepting of our NMDA receptor hypofunction (NRH) hypothesis of schizophrenia, but they argue that NRH could arise from reduced cortical connectivity rather than receptor dysfunction per se, and in their closing paragraphs they introduce a neurodevelopmental twist (faulty synaptic pruning) that they would like to see emphasized in an alternate framing of our hypothesis.
Implicit in their letter is the suggestion that reduced cortical connectivity, faulty synaptic pruning, and a neu
Olney JW, Farber NB. N-Methyl-D-Aspartate Receptor Hypofunction in Schizophrenia Could Arise From Reduced Cortical Connectivity Rather Than Receptor Dysfunction-Reply. Arch Gen Psychiatry. 1997;54(6):579-580. doi:10.1001/archpsyc.1997.01830180097018