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Sep 2011

Incorrect Data in: Association of Genetic Variants on 15q12 With Cortical Thickness and Cognition in Schizophrenia

Arch Gen Psychiatry. 2011;68(9):880. doi:10.1001/archpsyc.68.9.880

Incorrect Data. In the Original Article titled“Association of Genetic Variants on 15q12 With Cortical Thickness and Cognition in Schizophrenia” by Bakken et al, published in the August issue of the Archives (2011;68[8]:781-790), incorrect P values appear in the text, Table 1, and Figures 1 and 4 and the accompanying figure legends. In addition, the text in the“Results” section of the abstract on page 781 should read as follows:“Two closely linked genetic variants (rs4906844 and rs11633924) within the Prader-Willi and Angelman syndrome region on chromosome 15q12 showed a genome-wide significant association (P = 1.08 × 10−8) with average cortical thickness and modest association with cognitive performance (permuted P = .03) specifically among patients diagnosed as having schizophrenia.” On page 782, in the right-hand column, under the“Genotype” subheading, the third sentence should have read as follows:“A total of 597 198 SNPs passed quality control filters (call rate >95%, minor allele frequency >5%, Hardy-Weinberg disequilibrium P < 1 × 10−6) and were merged with HapMap 3 reference populations.” Also, on page 785, in the right-hand column in the first full paragraph, the third sentence should read as follows:“Furthermore, in a combined sample of patients with schizophrenia and controls, the SNP × diagnosis interaction P value is significant (P = 1.56 × 10−7) but less significant than the initial finding among patients with schizophrenia.” Also, on page 787, in the left-hand column in the first full paragraph, the second sentence should read as follows:“Twenty-one SNPs were significantly associated (P < 1 × 10−7) with average cortical thickness and are closely linked (r2 > 0.7) to rs4906844.” The fourth sentence in the same paragraph should read as follows:“Five imputed SNPs show more significant association with cortical thickness than rs4906844 and are within 3.5 kb downstream of this SNP.” On the same page, in the first paragraph beneath the“Comment” heading, the first sentence should read as follows:“In this study, we identified a common genetic variant that is associated with cortical thickness with genome-wide significance (P = 1.1 × 10−8), specifically in schizophrenia.” This article was corrected online.

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