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February 2017 - July 1959

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September 1, 2010, Vol 67, No. 9, Pages 876-972

This Month in Archives of General Psychiatry

This Month in Archives of General Psychiatry

Abstract Full Text
Arch Gen Psychiatry. 2010;67(9):877-877. doi:10.1001/archgenpsychiatry.2010.104
Art and Images in Psychiatry

Picasso's Guernica

Abstract Full Text
Arch Gen Psychiatry. 2010;67(9):878-878. doi:10.1001/archgenpsychiatry.2010.108
Original Article

Modification of Cognitive Performance in Schizophrenia by Complexin 2 Gene Polymorphisms

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Arch Gen Psychiatry. 2010;67(9):879-888. doi:10.1001/archgenpsychiatry.2010.107

Neonatal Vitamin D Status and Risk of SchizophreniaA Population-Based Case-Control Study

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Arch Gen Psychiatry. 2010;67(9):889-894. doi:10.1001/archgenpsychiatry.2010.110

Effect of Antipsychotic Medication Alone vs Combined With Psychosocial Intervention on Outcomes of Early-Stage SchizophreniaA Randomized, 1-Year Study

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Arch Gen Psychiatry. 2010;67(9):895-904. doi:10.1001/archgenpsychiatry.2010.105

Impaired Intellect and MemoryA Missing Link Between Genetic Risk and Schizophrenia?

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Arch Gen Psychiatry. 2010;67(9):905-913. doi:10.1001/archgenpsychiatry.2010.99

Individuals, Schools, and NeighborhoodA Multilevel Longitudinal Study of Variation in Incidence of Psychotic Disorders

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Arch Gen Psychiatry. 2010;67(9):914-922. doi:10.1001/archgenpsychiatry.2010.101

Birth Weight, Schizophrenia, and Adult Mental DisorderIs Risk Confined to the Smallest Babies?

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Arch Gen Psychiatry. 2010;67(9):923-930. doi:10.1001/archgenpsychiatry.2010.100

Bipolar Disorder and Violent CrimeNew Evidence From Population-Based Longitudinal Studies and Systematic Review

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Arch Gen Psychiatry. 2010;67(9):931-938. doi:10.1001/archgenpsychiatry.2010.97

Genetic Variation in CACNA1C Affects Brain Circuitries Related to Mental Illness

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Arch Gen Psychiatry. 2010;67(9):939-945. doi:10.1001/archgenpsychiatry.2010.96

Correlation of Glutamate Levels in the Anterior Cingulate Cortex With Self-reported Impulsivity in Patients With Borderline Personality Disorder and Healthy Controls

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Arch Gen Psychiatry. 2010;67(9):946-954. doi:10.1001/archgenpsychiatry.2010.93
ContextDysfunction and deficits in the structure of the anterior cingulate cortex have been reported in borderline personality disorder (BPD). To our knowledge, there is only 1 published study to date investigating anterior cingulate cortex metabolism in subjects with BPD and co-occurring attention-deficit/hyperactivity disorder using proton magnetic resonance spectroscopy. Impulsivity is a key feature of BPD and can be related to anterior cingulate cortex function.ObjectiveTo investigate whether anterior cingulate cortex metabolism may be altered in BPD and correlates with BPD pathology.DesignCross-sectional proton magnetic resonance spectroscopy study.SettingDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany.Participants and PatientsThirty unmedicated female subjects meeting DSM-IV criteria for BPD and 31 age-matched healthy female control participants.Main Outcome MeasuresNeurometabolite concentrations in the anterior cingulate cortex and correlation of glutamate levels with self-reported measures of impulsivity and severity of borderline symptoms.ResultsSignificantly higher levels of glutamate in the anterior cingulate cortex were found in subjects with BPD as compared with healthy controls. A positive correlation between glutamate concentration and the Barratt Impulsiveness Scale total score as well as between glutamate concentration and the subscore for cognitive impulsivity were observed irrespective of diagnosis. We also found a positive correlation between glutamate concentrations and dissociation as well as between glutamate concentration and subscores of the Borderline Symptom List in the patient group.ConclusionsOur results support the hypothesis that higher glutamate concentration in the anterior cingulate cortex is associated with both severity of BPD symptoms and subjective impulsivity ratings, the latter independent of BPD. Further studies should confirm the association between enhanced glutamate concentration in the anterior cingulate cortex and behavioral measures of impulsivity.

Enlargement of Thalamic Nuclei in Tourette Syndrome

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Arch Gen Psychiatry. 2010;67(9):955-964. doi:10.1001/archgenpsychiatry.2010.102

Reduced Brain White Matter Integrity in TrichotillomaniaA Diffusion Tensor Imaging Study

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Arch Gen Psychiatry. 2010;67(9):965-971. doi:10.1001/archgenpsychiatry.2010.109
Letters to the Editor

Letters to the Editor

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Arch Gen Psychiatry. 2010;67(9):972-972. doi:10.1001/archgenpsychiatry.2010.103

Antiepileptic Drugs and Suicide Attempts in Patients With Bipolar Disorder

Abstract Full Text
Arch Gen Psychiatry. 2010;67(9):972-972. doi:10.1001/archgenpsychiatry.2010.103
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