Daly and colleagues conducted a double-blind, placebo-controlled crossover trial of acute tryptophan depletion and functional magnetic resonance imaging to compare the effects of acute tryptophan depletion on brain responses to primary facial expressions of emotion in men with autism spectrum disorders and healthy control subjects.
In a prospective study, Green and coauthors investigated guilt-selective decoupling between the subgenual cingulate cortex and adjacent septal region and the anterior temporal lobe in patients with remitted major depressive disorder compared with healthy control participants.
Slopen and colleagues drew data from the Bucharest Early Intervention Project, a cohort of children raised in institutions in Romania and an age-matched sample of community control subjects. The aim was to examine whether abnormalities in the neural processing of facial and emotional stimuli are related to the high rates of psychopathology observed among institutionally reared children.
In a prospective study, Teplin and coauthors examine changes in the prevalence and persistence of psychiatric disorders during the 5 years after detention of 1829 youths, focusing on sex and racial/ethnic differences.
To determine whether long-term interferon alfa administration reduces the basal ganglia response to reward and whether such changes are associated with decreased presynaptic striatal dopamine function and altered behavior, Capuron and coauthors studied medically stable adults with chronic hepatitis C virus infection.
Insomnia has been implicated in impaired workplace functioning, but employers have not invested in workplace screening and treatment. Shahly et al estimated the prevalence and costs to employers of insomnia-related accidents and/or errors and made annualized national projections to the entire US workforce.
Focused hypnotic concentration is a model for brain control over sensation and behavior. Pain and anxiety can be effectively alleviated by hypnotic suggestion, which modulates activity in brain regions associated with focused attention. Hoeft and associates investigate the brain basis of hypnotizability.
Byers et al used latent class growth curve analysis to characterize the natural course of depressive symptoms among 7240 community-dwelling women 65 years or older who were enrolled at 4 clinic sites in an ongoing prospective cohort study and were followed up for almost 20 years. The Geriatric Depression Scale short form (GDS) was routinely administered.
Kuo et al compare amygdala volumes between 99 combat veterans with and without PTSD and examine the effect of trauma exposure in childhood and the severity of combat exposure in adulthood.
Kluetsch et al connect the previously separate research areas of default mode network connectivity and altered pain perception in borderline personality disorder (BPD) and explore default mode network connectivity during pain processing in patients with BPD.