To determine whether a family history of schizophrenia and/or bipolar disorder is a risk factor for autism spectrum disorders (ASDs), Sullivan and colleagues conducted a case-control evaluation of histories of schizophrenia or bipolar disorder in first-degree relatives of probands in 3 samples—population registers in Sweden, Stockholm County, and Israel.
Gibbons and coauthors describe a computerized adaptive test for depression that decreases patient and clinician burden and increases measurement precision.
To examine past, study intake, and follow-up predictors of prospectively examined suicide attempts among youth with bipolar disorder, Goldstein and coauthors interviewed subjects, on average, every 9 months over a mean of 5 years using the Longitudinal Interval Follow-up Evaluation.
In this register-based prospective cohort study, Pedersen et al examine whether Toxoplasma gondii–infected mothers have an increased risk of self-directed violence, violent suicide attempts, and suicide and whether the risk depends on the level of T gondii IgG antibodies.
McLaughlin and coauthors evaluate epidemiologic data on the prevalence and correlates of intermittent explosive disorder in 6483 adolescents.
D’Onofrio and colleagues used a quasi-experimental study to examine whether other environmental and genetic risks for offspring substance use confound the causal relationship between maternal smoking during pregnancy and substance use/problems among adolescent and adult offspring.
To examine the multivariate associations of 12 childhood adversities (CAs) with first onset of psychiatric disorders, McLaughlin and colleagues assessed lifetime DSM-IV anxiety, mood, behavior, and substance use disorders and CAs in 6483 US adolescent-parent pairs using the World Health Organization Composite International Diagnostic Interview.
Telch et al evaluate the use of a single 35% CO2 challenge administered before deployment as a predictor of soldiers’ risk for PTSD and anxiety while in the war zone.
The amygdala is strongly implicated in the pathophysiology of PTSD. Morey et al used magnetic resonance imaging to assess amygdala volume in a cohort of military veterans with and without PTSD.