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December 1, 2012, Vol 69, No. 12, Pages 1192-1313

This Month in Archives of General Psychiatry

This Month in Archives of General Psychiatry

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Arch Gen Psychiatry. 2012;69(12):1193-1193. doi:10.1001/archgenpsychiatry.2011.1239
Art and Images in Psychiatry

El Greco's The Penitent Magdalene

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Arch Gen Psychiatry. 2012;69(12):1194-1194. doi:10.1001/archgenpsychiatry.2012.111
Original Article

Improvement of Brain Reward Abnormalities by Antipsychotic Monotherapy in Schizophrenia

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Arch Gen Psychiatry. 2012;69(12):1195-1204. doi:10.1001/archgenpsychiatry.2012.847

In a longitudinal cohort study, Nielsen et al investigate changes in reward-related brain activations in schizophrenia before and after antipsychotic monotherapy with a dopamine D2/D3 antagonist.

A System-Level Transcriptomic Analysis of Schizophrenia Using Postmortem Brain Tissue Samples

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Arch Gen Psychiatry. 2012;69(12):1205-1213. doi:10.1001/archgenpsychiatry.2012.704

Roussos and coauthors identify abnormalities in the transcriptome organization among older persons with schizophrenia and controls by using gene coexpression network analysis.

From Perception to Functional Outcome in SchizophreniaModeling the Role of Ability and Motivation

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Arch Gen Psychiatry. 2012;69(12):1216-1224. doi:10.1001/archgenpsychiatry.2012.652

In a cross-sectional study, Green et al evaluate theoretically based models of pathways to functional outcome starting with early visual perception.

Neural Correlates of Weight Gain With Olanzapine

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Arch Gen Psychiatry. 2012;69(12):1226-1237. doi:10.1001/archgenpsychiatry.2012.934

In an event-related functional magnetic resonance imaging study, Mathews et al test the hypothesis that olanzapine treatment disrupts the neural activity associated with the anticipation and receipt (consumption) of food rewards.

Highly Penetrant Alterations of a Critical Region Including BDNF in Human Psychopathology and Obesity

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Arch Gen Psychiatry. 2012;69(12):1238-1246. doi:10.1001/archgenpsychiatry.2012.660

In a case-control study, Ernst et al determine the involvement of BDNF in human psychopathology.

National Trends in the Office-Based Treatment of Children, Adolescents, and Adults With Antipsychotics

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Arch Gen Psychiatry. 2012;69(12):1247-1256. doi:10.1001/archgenpsychiatry.2012.647

Olfson and coauthors compare national trends and patterns in antipsychotic treatment of adults and youths in office-based medical practice.

Parametric Modulation of Neural Activity by Emotion in Youth With Bipolar Disorder, Youth With Severe Mood Dysregulation, and Healthy Volunteers

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Arch Gen Psychiatry. 2012;69(12):1257-1266. doi:10.1001/archgenpsychiatry.2012.913

Thomas et al compared activation in the amygdala and across the brain on subtle changes in facial emotion between youth with bipolar disorder, youth with severe mood dysregulation, and healthy volunteers.

Prefrontal Cortical Deficits in Type 1 Diabetes MellitusBrain Correlates of Comorbid Depression

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Arch Gen Psychiatry. 2012;69(12):1267-1276. doi:10.1001/archgenpsychiatry.2012.543

Lyoo and colleagues conducted a case-control study of 125 patients with type 1 diabetes mellitus (T1DM), 23 subjects without T1DM but with 1 or more previous depressive episodes, and 38 healthy subjects to investigate neuroanatomic correlates of depression in T1DM.

Psychotic Symptoms in Adolescence Index Risk for Suicidal BehaviorFindings From 2 Population-Based Case-Control Clinical Interview Studies

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Arch Gen Psychiatry. 2012;69(12):1277-1283. doi:10.1001/archgenpsychiatry.2012.164

Using 2 independently conducted case-control clinical interview studies, Kelleher et al explore associations between psychotic symptoms in nonpsychotic adolescents and risk for suicidal behavior in (1) the general population, (2) adolescents with psychiatric disorder, and (3) adolescents with suicidal ideation.

Differential Mental Health Effects of Neighborhood Relocation Among Youth in Vulnerable FamiliesResults From a Randomized Trial

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Arch Gen Psychiatry. 2012;69(12):1284-1294. doi:10.1001/archgenpsychiatry.2012.449

Osypuk and coauthors used experimental evidence from the Moving to Opportunity trial to assess whether gender and family health problems modify the mental health effects in adolescents of moving from high- to low-poverty neighborhoods.

Clinical and Functional Outcome of Childhood Attention-Deficit/Hyperactivity Disorder 33 Years Later

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Arch Gen Psychiatry. 2012;69(12):1295-1303. doi:10.1001/archgenpsychiatry.2012.271

Klein and coauthors performed a 33-year follow-up of the clinical and functional outcomes of children diagnosed as having attention-deficit/hyperactivity disorder at 8 years of age.

Birth Cohort Effects on Adolescent Alcohol UseThe Influence of Social Norms From 1976 to 2007

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Arch Gen Psychiatry. 2012;69(12):1304-1313. doi:10.1001/archgenpsychiatry.2012.787

Keyes et al investigate whether adolescents in birth cohorts and/or time periods characterized by restrictive social norms toward alcohol were at decreased risk for alcohol use and binge drinking, controlling for individual attitudes (disapproval) toward use.

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