In a longitudinal cohort study, Nielsen et al investigate changes in reward-related brain activations in schizophrenia before and after antipsychotic monotherapy with a dopamine D2/D3 antagonist.
Roussos and coauthors identify abnormalities in the transcriptome organization among older persons with schizophrenia and controls by using gene coexpression network analysis.
In a cross-sectional study, Green et al evaluate theoretically based models of pathways to functional outcome starting with early visual perception.
In an event-related functional magnetic resonance imaging study, Mathews et al test the hypothesis that olanzapine treatment disrupts the neural activity associated with the anticipation and receipt (consumption) of food rewards.
In a case-control study, Ernst et al determine the involvement of BDNF in human psychopathology.
Olfson and coauthors compare national trends and patterns in antipsychotic treatment of adults and youths in office-based medical practice.
Thomas et al compared activation in the amygdala and across the brain on subtle changes in facial emotion between youth with bipolar disorder, youth with severe mood dysregulation, and healthy volunteers.
Lyoo and colleagues conducted a case-control study of 125 patients with type 1 diabetes mellitus (T1DM), 23 subjects without T1DM but with 1 or more previous depressive episodes, and 38 healthy subjects to investigate neuroanatomic correlates of depression in T1DM.
Using 2 independently conducted case-control clinical interview studies, Kelleher et al explore associations between psychotic symptoms in nonpsychotic adolescents and risk for suicidal behavior in (1) the general population, (2) adolescents with psychiatric disorder, and (3) adolescents with suicidal ideation.
Osypuk and coauthors used experimental evidence from the Moving to Opportunity trial to assess whether gender and family health problems modify the mental health effects in adolescents of moving from high- to low-poverty neighborhoods.
Klein and coauthors performed a 33-year follow-up of the clinical and functional outcomes of children diagnosed as having attention-deficit/hyperactivity disorder at 8 years of age.
Keyes et al investigate whether adolescents in birth cohorts and/or time periods characterized by restrictive social norms toward alcohol were at decreased risk for alcohol use and binge drinking, controlling for individual attitudes (disapproval) toward use.