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May 1, 2012, Vol 69, No. 5, Pages 443-537

This Month in Archives of General Psychiatry

This Month in Archives of General Psychiatry

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Arch Gen Psychiatry. 2012;69(5):444. doi:10.1001/archgenpsychiatry.2011.1204
Art and Images in Psychiatry

Unemployment

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Arch Gen Psychiatry. 2012;69(5):445. doi:10.1001/archgenpsychiatry.2012.104
Editorial

Changes in JAMA and the Archives of General PsychiatryWhat They Mean for Readers and Authors

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Arch Gen Psychiatry. 2012;69(5):447-448. doi:10.1001/archgenpsychiatry.2012.398
Original Article

ONLINE FIRST

Elevated Prefrontal Cortex γ-Aminobutyric Acid and Glutamate-Glutamine Levels in Schizophrenia Measured In Vivo With Proton Magnetic Resonance Spectroscopy

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Arch Gen Psychiatry. 2012;69(5):449-459. doi:10.1001/archgenpsychiatry.2011.1519

In a case-control study, Kegeles et al measure γ-aminobutyric acid and glutamate-glutamine levels in vivo in 2 prefrontal brain regions in unmedicated and medicated patients with schizophrenia and healthy controls.

A Population-Based Study of Shared Genetic Variation Between Premorbid IQ and Psychosis Among Male Twin Pairs and Sibling Pairs From Sweden

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Arch Gen Psychiatry. 2012;69(5):460-466. doi:10.1001/archgenpsychiatry.2011.1370

The relationship and shared genetic origin between premorbid IQ and psychotic disorders in a longitudinal population-based cohort is examined by Fowler et al.

Self-reported Attenuated Psychotic Symptoms as Forerunners of Severe Mental Disorders Later in Life

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Arch Gen Psychiatry. 2012;69(5):467-475. doi:10.1001/archgenpsychiatry.2011.1580

Werbeloff et al investigate the suggestion that attenuated psychotic symptoms reported by people who do not have psychotic disorders signal risk for later severe mental illness. They use follow-up assessments of hospitalization for clinical diagnoses of nonaffective psychotic and other psychiatric disorders.

Polypharmacy With Antipsychotics, Antidepressants, or Benzodiazepines and Mortality in Schizophrenia

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Arch Gen Psychiatry. 2012;69(5):476-483. doi:10.1001/archgenpsychiatry.2011.1532

Tiihonen et al investigate if the use of benzodiazepines, antidepressants, or multiple concomitant antipsychotics is associated with increased mortality among patients with schizophrenia and conclude that benzodiazepine use may contribute to mortality among this patient population worldwide.

Lifetime History of Depression and Anxiety Disorders as a Predictor of Quality of Life in Midlife Women in the Absence of Current Illness Episodes

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Arch Gen Psychiatry. 2012;69(5):484-492. doi:10.1001/archgenpsychiatry.2011.1578

Joffe et al evaluate whether previous affective illness is associated with low health-related quality of life during midlife in the absence of current illness episodes.

Midlife vs Late-Life Depressive Symptoms and Risk of DementiaDifferential Effects for Alzheimer Disease and Vascular Dementia

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Arch Gen Psychiatry. 2012;69(5):493-498. doi:10.1001/archgenpsychiatry.2011.1481

Barnes and coauthors examined depressive symptoms assessed in midlife and late life to assess the timing and nature of depression as etiologic risk factors for dementia.

Effect of Purpose in Life on the Relation Between Alzheimer Disease Pathologic Changes on Cognitive Function in Advanced Age

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Arch Gen Psychiatry. 2012;69(5):499-504. doi:10.1001/archgenpsychiatry.2011.1487

Boyle and coauthors used data from a longitudinal epidemiologic, clinicopathologic study of aging that included detailed annual clinical evaluations and brain autopsy to determine the risk of Alzheimer disease in persons with a strong sense of purpose in life.

Cost-effectiveness of a Multicondition Collaborative Care InterventionA Randomized Controlled Trial

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Arch Gen Psychiatry. 2012;69(5):506-514. doi:10.1001/archgenpsychiatry.2011.1548

Katon et al evaluate the cost-effectiveness of a multicondition collaborative treatment program compared with usual primary care in outpatients with depression and poorly controlled diabetes mellitus or coronary heart disease.

A Randomized Controlled Trial of Risperidone, Lithium, or Divalproex Sodium for Initial Treatment of Bipolar I Disorder, Manic or Mixed Phase, in Children and Adolescents

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Arch Gen Psychiatry. 2012;69(5):515-528. doi:10.1001/archgenpsychiatry.2011.1508

Geller and coauthors investigate which medication to administer first to antimanic medication–naive subjects. The Treatment of Early Age Mania study recruited 6- to 15-year-old children and adolescents with DSM-IV bipolar I disorder (manic or mixed phase) at 5 US sites from 2003 to 2008 into a controlled, randomized, no-patient-choice, 8-week protocol.

Association of Leptin With Food Cue–Induced Activation in Human Reward Pathways

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Arch Gen Psychiatry. 2012;69(5):529-537. doi:10.1001/archgenpsychiatry.2011.1586

In a case-control study, Grosshans and coauthors assess changes in regional brain activations in response to food-related cues in association with body mass index and the plasma concentration of the appetite regulating peptide leptin.

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