Sheng and coauthors compare the copy number intensities of genes associated with GAD67 regulation in the stratum oriens of sectors CA3/2 and CA1 in patients with schizophrenia, patients with bipolar disorder, and healthy controls. Samples of sectors CA3/2 and CA1 were obtained from patients with schizophrenia, patients with bipolar disorder, and healthy controls.
Watts et al examined the effect of implementation of the Mental Health Environment of Care Checklist and abatement process designed to remove suicide hazards from inpatient mental health units in all Veterans Health Administration hospitals. They measured change in the rate of suicides before and after the intervention.
Gara and colleagues studied whether African American individuals would continue to exhibit significantly higher rates of clinical diagnoses of schizophrenia, even after controlling for age, sex, income, site, and education, as well as the presence or absence of serious affective disorder, as determined by experts blinded to race and ethnicity.
Yatham and coauthors administered tryptophan-deficient amino acids to 17 patients with remission of major depressive disorder and, using positron emission tomography, evaluated the effects on brain levels of serotonin2 receptors.
Nosarti and coauthors investigate the relationships among gestational age, nonoptimal fetal growth, Apgar score, and various psychiatric disorders in young adult life using population-based data from Sweden.
Fagundes and colleagues address associations among recent severe life events, childhood parental emotional maltreatment, depression, and messenger RNA coding for immune markers associated with basal cell carcinoma tumor progression and regression.
In a cohort study, Sabia et al examine the association between smoking history and cognitive decline in the transition from midlife to old age.
Ligthart and coauthors assess the relationship between symptoms of apathy and cardiovascular risk factors or disease (stroke or other) in a large sample of elderly people aged 70 to 78 years without depression or dementia who were included in the Prevention of Dementia by Intensive Vascular Care trial.
In a meta-analysis, Fusar-Poli et al quantitatively examine the cognitive functioning in subjects at clinical high risk of psychosis in the literature until January 2011.
Gibbons et al determine the short-term efficacy of antidepressants for treating major depressive disorder in youth, adult, and geriatric populations. In a companion article, they determine the short-term safety of antidepressants by standard assessments of suicidal thoughts and behavior in these populations and the mediating effect of changes in depressive symptoms.
Gibbons et al determine the short-term safety of antidepressants by standard assessments of suicidal thoughts and behavior in youth, adult, and geriatric populations and the mediating effect of changes in depressive symptoms. In a companion article, they determine the short-term efficacy of antidepressants for treating major depressive disorder in these populations.