Guller et al test the hypothesis that direct physiological stimulation of the cortex will produce an abnormal thalamic response in individuals with schizophrenia.
Maintenance antidepressant treatment in late life prevents recurrent depressive episodes. Zhang et al studied the effects of the Medicare Part D coverage gap on medication use among aged beneficiaries with depression nationally to determine whether this population reduced their use of antidepressants in the Part D coverage gap.
To examine whether the results of different magnetic resonance imaging techniques are complementary, Sexton and coauthors used multimodal magnetic resonance imaging to compare gray matter, white matter, and resting-state networks between late-life depression and control groups.
To determine how genetic and environmental factors contribute to the risk for drug abuse (DA), Kendler and colleagues conducted follow-up in 9 public databases (1961-2009) of adopted children and their biological and adoptive relatives in Sweden.
Wolf and coauthors examined evidence for a distinct subtype of PTSD characterized by high levels of dissociation by using a latent profile analysis of cross-sectional data from structured clinical interviews indexing DSM-IV symptoms of current PTSD and dissociation in veterans and their intimate partners, all of whom had a history of trauma.
Using a prospective population-based study from fetal life onward, El Marroun et al examine the effects of maternal selective serotonin reuptake inhibitor use during pregnancy on fetal growth and birth outcomes.
Little is known about the effects of newer antipsychotics when used during pregnancy. Using Swedish national health registers, Bodén and colleagues compared populations of women who used different antipsychotics with those who remained unexposed and studied the prevalence of gestational diabetes and effects on fetal growth.
Labonté and coauthors performed a genome-wide study of promoter methylation in individuals with severe abuse during childhood to determine genome-wide DNA methylation alterations induced by early-life trauma.
Agrawal and coauthors investigate whether a synonymous CNR1 polymorphism, rs1049353, is linked to the effects of stress associated with childhood physical abuse on anhedonia and anhedonic depression.
To test the hypothesis that patients with obsessive-compulsive disorder demonstrate an increased response of relevant ventromedial prefrontal and orbitofrontal cortex regions in a functional magnetic resonance imaging study of difficult moral decision making, Harrison and coauthors used 24 hypothetical moral dilemma vs nondilemma task vignettes.
To investigate the GABAergic component of ADHD using magnetic resonance spectroscopy, Edden and colleagues compared children (age range, 8-12 years) in a typically developing control group vs a group with ADHD. J-difference–edited magnetic resonance spectroscopy at 3 T was used to measure GABA concentration in a volume that included primary somatosensory and motor cortices.