Carrión et al develop a predictive model of functional (social and role) outcome in a clinical high-risk sample for psychosis.
Fornito and colleagues used resting-state functional magnetic resonance imaging to characterize disease-related, risk-related, and symptom-related changes of corticostriatal functional circuitry in patients with first-episode psychosis and their unaffected, first-degree relatives.
Jarrett and colleagues tested the efficacy of continuation phase cognitive therapy and fluoxetine for relapse prevention in a placebo-controlled randomized trial and compared the durability of prophylaxis after discontinuation of treatments.
Beardslee et al determine whether the positive effects of a group cognitive-behavioral prevention (CBP) program extended to longer-term (multiyear) follow-up.
In an observational, longitudinal study, Judd and coauthors determine the prevalence of overtly expressed irritability/anger and its effect on intake presentation and the long-term course of illness.
In a 6-month double-blind trial, Heller and coauthors examine changes in the neural circuits involved in emotion regulation resulting from 1 of 2 antidepressant treatments. See also the editorial by Miller.
Simpson et al compare the effects of 2 serotonin reuptake inhibitor augmentation strategies, risperidone or cognitive-behavioral therapy consisting of exposure and ritual prevention, vs pill placebo in adults with obsessive-compulsive disorder. See related editorial by Ressler.
Pietrzak et al performed a cross-sectional positron emission tomography study under resting conditions among 3 study groups (healthy adults, adults exposed to trauma who did not develop posttraumatic stress disorder (PTSD), and adults exposed to trauma who developed PTSD). The [11C]methylreboxetine-binding potential of norepinephrine transporter availability was measured in the locus coeruleus, and PTSD symptom severity was assessed.
Reichborn-Kjennerud et al determine the structure of genetic and environmental risk factors for the symptoms of borderline personality disorder.
Hall et al identify large-scale resting-state networks in patients with fragile X syndrome that differ from those in control individuals matched on age, IQ, and severity of behavioral and cognitive symptoms.
Ludvigsson and coauthors examine the association between autism spectrum disorders and celiac disease.
D’Onofrio et al estimate the extent to which the associations between early gestational age and offspring mortality and morbidity are the result of confounding factors in a population-based cohort study.
Wallace et al demonstrate a novel exploratory approach to moderation analysis with a sample of 291 adults from a randomized clinical trial that compared an empirically supported psychotherapy and selective serotonin reuptake inhibitor pharmacotherapy as treatments for depression.