Lane and coauthors examine the clinical and cognitive efficacy and safety of add-on treatment of sodium benzoate for schizophrenia.
Kotov et al examine the associations between symptom course and long-term outcome to identify natural boundaries within psychotic disorders. Kendler provides an editorial.
Winsper and colleagues aimed to determine whether there are subgroups of psychotic individuals characterized by different developmental trajectories to violent behavior.
In a combined 3-T structural magnetic resonance imaging and single-voxel proton magnetic resonance spectroscopy study, Kraguljac and coauthors evaluate hippocampal volumetric measures and neurometabolite levels in unmedicated patients with schizophrenia and the correlations between these markers. See the editorial by Öngür.
Dima et al determine whether genetic risk for bipolar disorder associated with CACNA1C rs1006737 and ANK3 rs10994336 is mediated through changes in regional activation and interregional connectivity of the facial affect–processing network.
Pearson et al investigate the hypothesis that there are independent associations between antenatal and postnatal depression with offspring depression and that the risk pathways are different.
To test the hypothesis that neurodegeneration and neuronal density in brainstem aminergic nuclei are related to late-life depression, Wilson et al performed a clinicopathological cohort study among 124 older persons without dementia who had annual evaluations (with self-report of depressive symptoms), died, and underwent a postmortem neuropathological examination.
McCarthy et al compare adults with a childhood diagnosis of attention-deficit/hyperactivity disorder (ADHD) and control subjects to determine the specific location of possible ADHD-related differences in resting-state functional connectivity.
Johnson et al determine the efficacy of topiramate vs placebo as a treatment for cocaine dependence.
Sigmon et al evaluate the relative efficacy of 1-, 2-, and 4-week buprenorphine tapering regimens and subsequent naltrexone therapy in outpatients with prescription opioid dependence.
Wen et al examine the effect of state-level substance use disorder (SUD) parity laws on state-aggregate SUD treatment rates and the effect of recent federal SUD parity legislation.
Iltis et al provide mental health researchers with practical approaches to (1) identify and define various intrinsic research risks, (2) communicate these risks to others (eg, potential participants, regulatory bodies, and society), (3) manage these risks during the course of a study, and (4) justify the risks.