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June 2017 - July 1959




June 2013, Vol 70, No. 6, Pages 553-647

In This Issue of JAMA Psychiatry

In This Issue of JAMA Psychiatry

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JAMA Psychiatry. 2013;70(6):563. doi:10.1001/jamapsychiatry.2013.67

Public Safety, Mental Disorders, and Guns

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JAMA Psychiatry. 2013;70(6):565-566. doi:10.1001/jamapsychiatry.2013.315
Art and Images in Psychiatry

Leonardo da Vinci's Mona Lisa

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JAMA Psychiatry. 2013;70(6):555-556. doi:10.1001/jamapsychiatry.2013.371

Psychiatric GeneticsAre We There Yet?

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JAMA Psychiatry. 2013;70(6):569-570. doi:10.1001/jamapsychiatry.2013.216

The Potential Value of a Negative FindingAn Illustrative Example

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JAMA Psychiatry. 2013;70(6):571-572. doi:10.1001/jamapsychiatry.2013.1116

Two Steps Forward, One Step Back?Implications of the Supreme Court's Health Reform Ruling for Individuals With Mental Illness

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JAMA Psychiatry. 2013;70(6):567-568. doi:10.1001/jamapsychiatry.2013.25

Golberstein and Busch discuss the implications of the Supreme Court’s ruling regarding the Affordable Care Act (ACA) on the care of individuals with mental health disorders.

Original Article

A Comprehensive Family-Based Replication Study of Schizophrenia Genes

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JAMA Psychiatry. 2013;70(6):573-581. doi:10.1001/jamapsychiatry.2013.288

Aberg et al sought to identify the specific genetic variants and pathways that increase susceptibility to schizophrenia in an effort to improve understanding of the molecular and biological mechanisms involved with the disease. See also the editorial by Hardy.

Support for the N -Methyl-D-Aspartate Receptor Hypofunction Hypothesis of Schizophrenia From Exome Sequencing in Multiplex Families

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JAMA Psychiatry. 2013;70(6):582-590. doi:10.1001/jamapsychiatry.2013.1195

Timms et al identify new genetic factors strongly predisposing to schizophrenia in families with multiple affected individuals with schizophrenia.

Genetic Association, Mutation Screening, and Functional Analysis of a Kozak Sequence Variant in the Metabotropic Glutamate Receptor 3 Gene in Bipolar Disorder

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JAMA Psychiatry. 2013;70(6):591-598. doi:10.1001/jamapsychiatry.2013.38

Kandaswamy et al examined genetic markers at the gene encoding the metabotropic glutamate receptor 3 to evaluate the allelic association with bipolar disorder.

Evidence for Multiple Genetic Factors Underlying DSM-IV Criteria for Major Depression

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JAMA Psychiatry. 2013;70(6):599-607. doi:10.1001/jamapsychiatry.2013.751

Kendler et al determine the structure of genetic and environmental risk factors for the 9 DSM-IV symptomatic MD criteria.

Deficits in Conditioned Fear Extinction in Obsessive-Compulsive Disorder and Neurobiological Changes in the Fear Circuit

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JAMA Psychiatry. 2013;70(6):608-618. doi:10.1001/jamapsychiatry.2013.914

Milad and colleagues conducted a cross-sectional, case-control, functional magnetic resonance imaging study examining the psychophysiological and neurobiological correlates of conditioned fear extinction in patients with obsessive-compulsive disorder (OCD).

Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder

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JAMA Psychiatry. 2013;70(6):619-629. doi:10.1001/jamapsychiatry.2013.173

Beucke et al determined regions of abnormal degree connectivity in 46 patients with obsessive-compulsive disorder (OCD) to investigate whether connectivity measures are affected by antidepressant medication in this population.

A Multisite, Double-blind, Placebo-Controlled Clinical Trial to Evaluate the Safety and Efficacy of Vigabatrin for Treating Cocaine Dependence

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JAMA Psychiatry. 2013;70(6):630-637. doi:10.1001/jamapsychiatry.2013.872

To evaluate the efficacy of vigabatrin to treat cocaine dependence, Somoza et al performed a 12-week trial among 186 treatment seekers, with follow-up visits at weeks 13, 16, 20, and 24. Participants received vigabatrin (3.0 g/d) or matched placebo, plus cognitive behavioral therapy and individual counseling for 13 weeks. See Editorial by Silverman.

Brain Response to Empathy-Eliciting Scenarios Involving Pain in Incarcerated Individuals With Psychopathy

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JAMA Psychiatry. 2013;70(6):638-645. doi:10.1001/jamapsychiatry.2013.27

Decety et al evaluated the differences in patterns of neural activity in 80 incarcerated individuals with psychopathy and incarcerated persons serving as controls during the perception of empathy-eliciting stimuli depicting other people experiencing pain.

Letters to the Editor

APOE ϵ 4, Aging, and Effects on White Matter Across the Adult Life Span

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JAMA Psychiatry. 2013;70(6):646-647. doi:10.1001/jamapsychiatry.2013.865