Schmidt and coauthors investigate whether dysfunctional brain connectivity during working memory
predates the onset of psychosis and whether connectivity parameters are related to antipsychotic
Wunderink et al conduct a long-term follow-up evaluation of a randomized clinical trial comparing maintenance treatment with dose reduction/discontinuation of antipsychotic drugs in patients with remitted first-episode psychosis. McGorry et al provide an editorial.
Blasi et al examine the functional effects of the serotonin receptor 2a (5-HT2AR) gene on 5-HT2AR
messenger RNA and protein expression, on prefrontal phenotypes linked with genetic risk for
schizophrenia, and on treatment with olanzapine.
Crump and coauthors examine the physical health effects of bipolar disorder using outpatient and
inpatient data for a national population.
Kelleher et al assessed psychotic symptoms (attenuated or frank) as a clinical marker of risk for
Eftekhari et al evaluated the effectiveness of prolonged exposure therapy as implemented in a
large number of veterans with posttraumatic stress disorder as part of ongoing efforts to transform
care in a large health care system.
Gaysina et al examine the relationship between maternal smoking during pregnancy and offspring
conduct problems among children reared by genetically related and genetically unrelated mothers.
Three studies using distinct but complementary research designs were used. Possible covariates were
controlled for in the analyses. See the Editorial by Slotkin.
Proton magnetic resonance spectroscopic imaging data were acquired longitudinally for children
with autism spectrum disorder or developmental delay and primarily cross-sectionally for children
with typical development by Corrigan and coauthors to examine cross-sectional and longitudinal
patterns of brain chemical concentrations from 3 different age groups, beginning early in the
Cardinale and colleagues examined the asymmetry of functional networks using a data-driven
approach for a comprehensive investigation of hemispheric asymmetry in autism spectrum disorder
Castrén describes the network hypothesis of antidepressant action that proposes that
recovery from depression and related mood disorders is a gradual process that develops slowly and is
facilitated by structured guidance and rehabilitation.