Meier et al assessed whether patients with obsessive-compulsive disorder (OCD) experience an enhanced risk of developing schizophrenia and schizophrenia spectrum disorders and whether a family history of OCD constitutes a risk factor for schizophrenia and schizophrenia spectrum disorders.
In a 2-center cross-sectional study, Redlich et al investigate and compare morphometric changes in unipolar depression (UD) and bipolar depression (BD), and replicate the findings at 2 independent neuroimaging sites. They conclude that individuals with UD and those with BD are differentiated by structural abnormalities in neural regions supporting emotion processing.
This retrospective analysis assesses the effects of sunshine on suicide incidence that are independent of seasonal variation.
This experimental study in humans and rats reports that organisms have diminished ability to modulate behavior as a function of reward during withdrawal of nicotine.
This prospective cohort study reports that achieving remission from a substance use disorder does not typically lead to drug substitution, but rather is associated with a lower risk of new substance use disorder onsets.
This case control study suggests that oleoylethanolamide-mediated signaling plays an important role for hedonic regulation of food-craving and obesity in humans and, thus, may be a valuable target for developing novel antiobesity drugs.
This cross-sectional study reports that κ-opioid receptor availability in an amygdala–anterior cingulate cortex–ventral striatal neural circuit mediates the phenotypic expression of trauma-related loss (ie, dysphoria) symptoms and that an activated corticotropin-releasing factor/hypothalamic-pituitary-adrenal axis system may indirectly mediate this association.
This cross-sectional analysis using the Nurses’ Health Study II cohort reports that posttraumatic stress disorder symptoms are associated with increased food addiction prevalence. Strategies aimed at reducing obesity associated with posttraumatic stress disorder may require psychological and behavioral interventions that address dependence on food and/or use of food to cope with distress.
This randomized trial suggests that the type of family therapy matters in the treatment of adolescent-onset anorexia nervosa.
This randomized clinical trial found that complicated grief (CG) treatment produced clinically and statistically significantly greater response rates for symptoms of CG in the elderly than a proven efficacious treatment for depression.