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June 2017 - July 1959




June 2014, Vol 71, No. 6, Pages 607-717

In This Issue of JAMA Psychiatry


Abstract Full Text
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JAMA Psychiatry. 2014;71(6):607. doi:10.1001/jamapsychiatry.2013.2733

Requests for Euthanasia/Physician-Assisted Suicide on the Basis of Mental SufferingVulnerable Patients or Vulnerable Physicians?

Abstract Full Text
JAMA Psychiatry. 2014;71(6):617-618. doi:10.1001/jamapsychiatry.2014.185

Addressing the Cost of Health Care From the Front Lines of Psychiatry

Abstract Full Text
JAMA Psychiatry. 2014;71(6):619-620. doi:10.1001/jamapsychiatry.2014.121
Art and Images in Psychiatry

The Head of MedusaPeter Paul Rubens and Frans Snyders

Abstract Full Text
JAMA Psychiatry. 2014;71(6):614-615. doi:10.1001/jamapsychiatry.2013.2735

BitopertinThe Good News and Bad News

Abstract Full Text
JAMA Psychiatry. 2014;71(6):621-622. doi:10.1001/jamapsychiatry.2014.257

The Social Brain, Stress, and Psychopathology

Abstract Full Text
JAMA Psychiatry. 2014;71(6):622-624. doi:10.1001/jamapsychiatry.2014.288

Efficacy of Pharmacologic and Psychotherapeutic Interventions in PsychiatryTo Talk or to Prescribe: Is That the Question?

Abstract Full Text
JAMA Psychiatry. 2014;71(6):624-626. doi:10.1001/jamapsychiatry.2014.301
Original Investigation

Mediation of the Relationship Between Callous-Unemotional Traits and Proactive Aggression by Amygdala Response to Fear Among Children With Conduct Problems

Abstract Full Text
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JAMA Psychiatry. 2014;71(6):627-636. doi:10.1001/jamapsychiatry.2013.4540

Lozier and colleagues assessed the unique neurobiological covariates of callous-unemotional traits and externalizing behaviors in youths with conduct problems and determined whether neural dysfunction linked to callous-unemotional traits mediates the link between callousness and proactive aggression.

Effect of Bitopertin, a Glycine Reuptake Inhibitor, on Negative Symptoms of SchizophreniaA Randomized, Double-Blind, Proof-of-Concept Study

Abstract Full Text
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JAMA Psychiatry. 2014;71(6):637-646. doi:10.1001/jamapsychiatry.2014.163

Umbricht and colleagues aimed to determine the efficacy and safety of bitopertin, a glycine reuptake inhibitor, in patients with schizophrenia and predominant negative symptoms who were stable while taking an antipsychotic treatment. Goff provided a related Article .

Differential Effects of Common Variants in SCN2A on General Cognitive Ability, Brain Physiology, and messenger RNA Expression in Schizophrenia Cases and Control Individuals

Abstract Full Text
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JAMA Psychiatry. 2014;71(6):647-656. doi:10.1001/jamapsychiatry.2014.157

Dickinson and colleagues aimed to identify single-nucleotide polymorphisms associated with general cognitive ability in people with schizophrenia and control individuals.


Identification of Pathways for Bipolar DisorderA Meta-analysis

Abstract Full Text
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JAMA Psychiatry. 2014;71(6):657-664. doi:10.1001/jamapsychiatry.2014.176

Nurnberger et al identify biological pathways that contribute to risk for bipolar disorder using genes with consistent evidence for association in multiple genome-wide association studies.

Mitochondrial Dysfunction as a Neurobiological Subtype of Autism Spectrum DisorderEvidence From Brain Imaging

Abstract Full Text
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JAMA Psychiatry. 2014;71(6):665-671. doi:10.1001/jamapsychiatry.2014.179

Goh and colleagues assess brain lactate in individuals with autism spectrum disorder and typically developing controls using high-resolution, multiplanar spectroscopic imaging, and map the distribution of lactate in the brains of individuals with autism spectrum disorder, assessing correlations of elevated brain lactate with age, autism subtype, and intellectual ability.

Neuroimaging Evidence for a Role of Neural Social Stress Processing in Ethnic Minority–Associated Environmental Risk

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JAMA Psychiatry. 2014;71(6):672-680. doi:10.1001/jamapsychiatry.2014.35

Akdeniz et al study neural social stress processing, using functional magnetic resonance imaging, and associations with perceived discrimination in ethnic minority individuals. Wager and Gianaros provide commentary in a related editorial.

Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress DisorderA Randomized Clinical Trial

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JAMA Psychiatry. 2014;71(6):681-688. doi:10.1001/jamapsychiatry.2014.62

In a proof-of-concept, randomized, double-blind, crossover trial comparing ketamine with an active placebo control, midazolam, conducted at a single site, Feder and coauthors test the efficacy and safety of a single intravenous subanesthetic dose of ketamine for the treatment of posttraumatic stress disorder (PTSD) and associated depressive symptoms in patients with chronic PTSD.

Family-Based Treatment of Early Childhood Obsessive-Compulsive DisorderThe Pediatric Obsessive-Compulsive Disorder Treatment Study for Young Children (POTS Jr)—A Randomized Clinical Trial

Abstract Full Text
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JAMA Psychiatry. 2014;71(6):689-698. doi:10.1001/jamapsychiatry.2014.170

In a 14-week randomized clinical trial, Freeman and coauthors examine the relative efficacy of family-based cognitive behavior therapy involving exposure plus response prevention vs a family-based relaxation treatment control condition for children 5 to 8 years of age.

Overlapping Genetic and Environmental Influences on Nonsuicidal Self-injury and Suicidal IdeationDifferent Outcomes, Same Etiology?

Abstract Full Text
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JAMA Psychiatry. 2014;71(6):699-705. doi:10.1001/jamapsychiatry.2014.89

Maciejewski et al determine the relative importance of genetic and environmental influences on the variation in nonsuicidal self-injury and suicidal ideation and their covariation.


Efficacy of Pharmacotherapy and Psychotherapy for Adult Psychiatric DisordersA Systematic Overview of Meta-analyses

Abstract Full Text
JAMA Psychiatry. 2014;71(6):706-715. doi:10.1001/jamapsychiatry.2014.112

Huhn et al perform a systematic overview on the efficacy of pharmacotherapies and psychotherapies for major psychiatric disorders and compare the quality of pharmacotherapy and psychotherapy trials. See also the editorial by Correll and Carbon.

Comment & Response

Was Risk of Suicide Underestimated?

Abstract Full Text
JAMA Psychiatry. 2014;71(6):716. doi:10.1001/jamapsychiatry.2014.148

Selected Pregnancy and Delivery Outcomes After Exposure to Antidepressant Medication

Abstract Full Text
JAMA Psychiatry. 2014;71(6):716-717. doi:10.1001/jamapsychiatry.2014.59
JAMA Psychiatry Masthead

JAMA Psychiatry

Abstract Full Text
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JAMA Psychiatry. 2014;71(6):607-608. doi:10.1001/jamapsychiatry.2013.2734