Lozier and colleagues assessed the unique neurobiological covariates of callous-unemotional traits and externalizing behaviors in youths with conduct problems and determined whether neural dysfunction linked to callous-unemotional traits mediates the link between callousness and proactive aggression.
Umbricht and colleagues aimed to determine the efficacy and safety of bitopertin, a glycine reuptake inhibitor, in patients with schizophrenia and predominant negative symptoms who were stable while taking an antipsychotic treatment. Goff provided a related Article .
Dickinson and colleagues aimed to identify single-nucleotide polymorphisms associated with general cognitive ability in people with schizophrenia and control individuals.
Nurnberger et al identify biological pathways that contribute to risk for bipolar disorder using genes with consistent evidence for association in multiple genome-wide association studies.
Goh and colleagues assess brain lactate in individuals with autism spectrum disorder and typically developing controls using high-resolution, multiplanar spectroscopic imaging, and map the distribution of lactate in the brains of individuals with autism spectrum disorder, assessing correlations of elevated brain lactate with age, autism subtype, and intellectual ability.
Akdeniz et al study neural social stress processing, using functional magnetic resonance imaging, and associations with perceived discrimination in ethnic minority individuals. Wager and Gianaros provide commentary in a related editorial.
In a proof-of-concept, randomized, double-blind, crossover trial comparing ketamine with an active placebo control, midazolam, conducted at a single site, Feder and coauthors test the efficacy and safety of a single intravenous subanesthetic dose of ketamine for the treatment of posttraumatic stress disorder (PTSD) and associated depressive symptoms in patients with chronic PTSD.
In a 14-week randomized clinical trial, Freeman and coauthors examine the relative efficacy of family-based cognitive behavior therapy involving exposure plus response prevention vs a family-based relaxation treatment control condition for children 5 to 8 years of age.
Maciejewski et al determine the relative importance of genetic and environmental influences on the variation in nonsuicidal self-injury and suicidal ideation and their covariation.
Huhn et al perform a systematic overview on the efficacy of pharmacotherapies and psychotherapies for major psychiatric disorders and compare the quality of pharmacotherapy and psychotherapy trials. See also the editorial by Correll and Carbon.