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Invited Critique
Feb 2012

Statins for Everyone: Are We There Yet?Comment on “Effect of Perioperative Statins on Death, Myocardial Infarction, Atrial Fibrillation, and Length of Stay”

Author Affiliations

Author Affiliation: Department of Surgery, Stanford University, Stanford, California.

Arch Surg. 2012;147(2):189. doi:10.1001/archsurg.2011.1014

Chopra et al1 examined the effects of the lipid-lowering 3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitors (“statins”) on postoperative complications in patients who were naive to these medications. They performed a rigorous systematic review and meta-analysis of 15 studies with almost 2300 patients. The major findings were (1) 44% risk reduction for atrial fibrillation, with a number needed to treat of 6; (2) 47% risk reduction for myocardial infarction, with a number needed to treat of 23; and (3) a 32% reduction in hospital length of stay.

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