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Invited Critique
March 2013

The AppendixA Culprit for BRCA1 -Associated Intraperitoneal Cancer?
Comment on “Risk-Reducing Appendectomy and the Elimination of BRCA1 -Associated Intraperitoneal Cancer”

Author Affiliations

Author Affiliations: Department of Surgery, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts.

JAMA Surg. 2013;148(3):291. doi:10.1001/jamasurg.2013.1025

Women with inherited BRCA1/2 mutations have substantially elevated risks of breast and ovarian cancer, with 60% to 85% cumulative lifetime risk of invasive breast cancer and 10% to 63% risk of ovarian cancer.13 Prophylactic mastectomy and risk-reducing bilateral salpingo-oophorectomy (RRBSO) reduce the risk of both cancers and of cancer-specific and all-cause mortality in these patients.1

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