Experimental Surgery
January 1972

Effect of Diphenhydramine on Glycine-Produced Hyperammonemia in Dogs

Author Affiliations

From the Division of Surgery and Allen-Bradley Medical Science Laboratory, Medical College of Wisconsin, Milwaukee.

Arch Surg. 1972;104(1):81-82. doi:10.1001/archsurg.1972.04180010075019

Hyperammonemia produced by an infusion of glycine in dogs leads to death within four hours. Concurrent treatment with a total dose of 15 or 20 mg/kg of diphenhydramine hydrochloride (Benadryl) significantly reduces the mortality to 12%. Although the surviving animals have lower average peak ammonia levels, there is no dose-specific relationship between the dose of diphenhydramine and the level of hyperammonemia. The mechanism of action of diphenhydramine remains unanswered.