Intravenous injection of denatured globin hemochromogen, an artificially prepared substance yielding a spectroscopic pattern similar to that previously reported in prolonged shock, strangulation intestinal obstruction, and hemorrhagic necrotizing pancreatitis, causes detrimental effects on systemic and pulmonary hemodynamics. Nineteen dogs were tested and five others in whom human salt poor albumin was used instead of the hemochromogen were used as controls. The significant findings were a severe fall in the systemic blood pressure and in the cardiac output, a striking increase in the pulmonary vascular resistance, and an appreciable fall in the pH. Microscopic findings were consistent with those seen in the lungs in prolonged shock or in septic or traumatic states.
Habboushe F, Nemir P. Pulmonary Hemodynamics Following Injection of Denatured Globin Hemochromogen. Arch Surg. 1972;104(1):83-86. doi:10.1001/archsurg.1972.04180010077020