Experimental Surgery
January 1972

Detrimental Effects of Removal of the Renal Capsule Following Acute Ischemia

Author Affiliations

Oxford, England; Cambridge, England; Oxford, England
From the Nuffield Department of Surgery, Radcliffe Infirmary, Oxford, England (Drs. Milton and Craddock); and the Department of Biomathematics, Oxford University, Oxford, England (Dr. Brennan). Dr. Craddock is now with Addenbrooke's Hospital, Cambridge, England.

Arch Surg. 1972;104(1):90-94. doi:10.1001/archsurg.1972.04180010084022

The renal blood supply of 144 rats was occluded for specific periods of time between 120 and 270 minutes. In half the animals the renal capsule was removed. Function was assessed by the ability of the damaged kidney to maintain life after removal of the opposite organ three weeks later. Removal of the renal capsule was found to reduce life-span by two months, which was significant at the 5% level. It is recommended that capsulotomy should be abandoned in human renal transplantation until evidence is obtained of its benefit.