Since antiquity, written words in the form of a manuscript or book have proven to be an integral instrument of education and training for physicians and surgeons. At an equal pace with this has been never ending discussions about which publications are the most famous and influential in the history of medicine. There is little doubt that Vesalius' De Humani Corporis Fabrica Libri Septem, first published in 1543, would be included in any scholarly debate or list making. A cornerstone of the Renaissance's scientific revolution, printing of the Fabrica revolutionized not just the understanding of human anatomy but also how it was taught.
Rutkow IM. On the Fabric of the Human Body: A Translation of De Humani Corporis Fabrica Libri Septem: Book 1: The Bones and Cartilages. Arch Surg. 1998;133(11):1251. doi: