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Comment & Response
May 2015

Effect of Breast Cancer After Ovarian Cancer on Mortality for BRCA Mutation Carriers

Author Affiliations
  • 1Center for Observational Research, Amgen Inc, South San Francisco, California
  • 2Women’s College Research Institute, Toronto, Ontario, Canada
JAMA Surg. 2015;150(5):490-491. doi:10.1001/jamasurg.2015.0193

To the Editor Gangi et al1 describe survival among a cohort of 364 women who received a diagnosis of epithelial ovarian cancer with up to 14 years of follow-up (median follow-up, 5.1 years). They conclude that women with a BRCA1 or BRCA2 mutation (37% of the women in their sample) who subsequently develop breast cancer have a higher survival rate than those who do not. We are concerned that the conclusions regarding survival are subject to immortal time bias.

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