The ideal time interval for esophagectomy after neoadjuvant chemoradiotherapy (CRT) for patients with esophageal cancer is unknown, but in most centers, the operation is usually performed 4 to 8 weeks after CRT when the patient has fully recovered. A similar time interval between CRT and operation has traditionally been accepted for patients with rectal cancer; however, recent studies1,2 have suggested that a longer wait may increase the rate of pathologic complete responses (pCRs) and may improve survival.
Patti MG. Esophageal Resection for Cancer After Neoadjuvant ChemoradiationTo Wait or Not To Wait?. JAMA Surg. 2016;151(11):e162750. doi:10.1001/jamasurg.2016.2750