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Invited Commentary
January 18, 2017

Gastrointestinal Stromal Tumors in Younger PatientsA Start but More to Do!

Author Affiliations
  • 1Professorial Surgical Unit, Department of Surgery, The University of Dublin, Trinity College, Tallaght, Dublin, Ireland
JAMA Surg. Published online January 18, 2017. doi:10.1001/jamasurg.2016.5048

Although uncommon, gastrointestinal stromal tumors (GISTs) represent the most frequent mesenchymal tumor of the gastrointestinal tract. Our understanding of GISTs evolved after the discovery of KIT proto-oncogene receptor tyrosine kinase (c-KIT) and platelet-derived growth factor α (PDGFRA) mutations. Although GISTs are generally found in older adult (OA) patients, in this issue of JAMA Surgery Fero et al1 examine the occurrence of GISTs in adolescent and young adult (AYA) patients identified in the Surveillance, Epidemiology, and End Results database.

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