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Invited Commentary
March 15, 2017

Staging for Intrahepatic CholangiocarcinomaAre We Getting Close to Understanding the True Tumor Biology?

Author Affiliations
  • 1Department of Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York
  • 2Department of Surgery, University of Rochester, Rochester, New York
JAMA Surg. Published online March 15, 2017. doi:10.1001/jamasurg.2017.0108

The worldwide incidence of intrahepatic cholangiocarcinoma (ICC) is increasing, and the oncological outcomes are far from satisfactory. Lack of both an understanding of its tumor biology and a distinct staging system that gives us accurate prognostic value could be the reason for this disappointing outcome. Therefore, there is a need to develop a solid staging system that provides integrated guidance for the treatment of ICC. Historically, the hepatocellular carcinoma staging system had been applied to ICC until the seventh edition of American Joint Committee on Cancer (AJCC) classification was developed.

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