Preoperative chemotherapy and/or chemoradiation is considered today the standard of care for the treatment of locally advanced/borderline resectable pancreatic cancer (PDAC).1
With this regard, terms such as downstaging and neoadjuvant are commonly reported in medical literature and mutually used as synonyms to address preoperative treatment. A first important issue that should be pointed out is a matter of definitions.
Del Chiaro M, Valente R, Arnelo U. Neoadjuvant Treatment in Locally Advanced and Borderline Resectable Pancreatic Cancer vs Primary Resectable Pancreatic Cancer. JAMA Surg. Published online July 12, 2017. doi:10.1001/jamasurg.2017.2228