edited by Maurice Markman, MD, 365 pp, with illus, ISBN 0-89603-729-0, Totowa, NJ, Humana Press, 2000.
A long overdue text on Regional Chemotherapy is available. Surgeons looking for innovative technical solutions to refractory cancers will be aided by an organized composite of articles from investigators currently active in the field. The editor introduces the basic rationale for a system of chemotherapy most often delivered surgically: the pharmacokinetic advantage of regional over systemic delivery measured by the ratio of drug concentrations of the 2 methods. The first passage of a drug to the localized cancer will give the highest therapeutic advantage, especially if given in a high concentration, and different methods of delivery as well as different drugs maximize the effect. Although the first chapter, written by the editor cuts quickly through the subject at hand in 4 pages, the remaining 21 chapters address technical issues and an essential question: Does regional chemotherapy change disease free survival?
Regional Chemotherapy: Clinical Research and Practice. Arch Surg. 2000;135(8):986. doi: