Dr Wick and colleagues add welcome data to ongoing evaluations of the immunologic effects of severe injury. Using a refined flow cytometric analysis, these investigators further define the effects of blunt trauma on the pattern and function of circulating lymphocytes: TH1 vs TH2 CD3+ cells. Prior studies have produced extremely variable results in the shift from TH1 to TH2 phenotype consistent with an increased risk for infectious and other immunologic complications.
Maier RV. The Potential Pattern of Circulating Lymphocytes TH1/TH2 Is Not Altered After Multiple Injuries—Invited Critique. Arch Surg. 2000;135(11):1314. doi:10.1001/archsurg.135.11.1314