Clinical Observation
December 2001

Blue UrticariaA Previously Unreported Adverse Event Associated With Isosulfan Blue

Author Affiliations

From the Department of Surgery, University of North Carolina Hospitals, Chapel Hill.


Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001

Arch Surg. 2001;136(12):1433-1435. doi:10.1001/archsurg.136.12.1433

The sentinel node hypothesis is predicated on the fact that a metastasis, if it exists, will have traveled on a direct path from the primary tumor through the efferent lymphatic channels to the first draining lymph node in the regional lymphatic basin, the sentinel node. Lymphatic mapping with isosulfan blue and sentinel lymphadenectomy is being increasingly used in the management of patients with melanoma, breast cancer, and other solid tumors. This trend is exposing an increasing number of patients to isosulfan blue. Although this compound is generally safe, severe reactions have been reported. We describe 2 patients who developed "blue hives" after isosulfan blue injection.