Colonic inertia is a poorly understood disease process. Few studies have investigated the molecular, humoral, and physiological mechanisms that govern motility in the large intestine. Recent data have pointed toward abnormalities in the specialized cells within the muscle layers of the bowel wall, known as ICC. These cells are thought to be involved with the myoelectrical activity of the colon. The role of ICC in colonic dysmotility and in disorders such as colonic inertia remains unknown.
Ramamoorthy SL. Electric Activity of the Colon in Subjects With Constipation Due to Total Colonic Inertia—Invited Critique. Arch Surg. 2003;138(9):1011. doi:10.1001/archsurg.138.9.1011