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Invited Critique
February 01, 2006

Novel Parathyroid Hormone (1-84) Assay as Basis for Parathyroid Hormone Monitoring in Renal Hyperparathyroidism—Invited Critique

Arch Surg. 2006;141(2):134. doi:10.1001/archsurg.141.2.134

Intraoperative PTH testing has revolutionized the way we treat patients with primary hyperparathyroidism (HPT) by allowing focused, “minimally invasive” procedures targeting resection of a single parathyroid adenoma.1 As shown by Irvin et al, Udelsman et al, our group, and others, intraoperative PTH testing (with first-generation assays) allows detection and subsequent resection of additional hyperfunctioning parathyroid glands intraoperatively, thereby improving cure rates following parathyroidectomy.25 Although the importance of intraoperative PTH testing in patients with primary HPT has been defined, its role in patients with secondary HPT is unclear.

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