We read with interest the comments by Dr Schmidt and feel that there are some points to consider. Our study was not aimed to prove that 1-dose prophylaxis is as effective as a 24-hour regimen. In fact, the objectives of this study were to demonstrate how to implement a 1-dose regimen in a general hospital. The fact that 1-dose prophylaxis reduces surgical site infections as effectively as a 24-hour regimen had already been demonstrated in innumerous trials, such as the one published by Scher.1 One-dose prophylaxis is a widely approved recommendation published in several guidelines,2 some of them cited in our article.
Fonseca SNS, Kunzle SRM, Junqueira MJ, Nascimento RT, Ivan de Andrade J, Levin ASS. Are Single-Dose Preoperative Antibiotic Regimens Really Appropriate?—Reply. Arch Surg. 2007;142(6):577. doi:10.1001/archsurg.142.6.577-a