The article by Steinert et al1 in the February issue of the Archives about the effect of subclinical metastasis in distant sites on disease-free survival (DFS) in patients who had curative resections for colorectal cancer (CRC) is high-powered and credible. Their conclusion is that subclinical metastasis does not affect the overall survival (OS) or DFS in these patients. This 9-year study was very well designed.
Badruddoja M. Significance of Subclinical Tumor Spreading in Colorectal Cancer. Arch Surg. 2008;143(11):1133-1134. doi:10.1001/archsurg.143.11.1133