We read with interest the article by Steinert et al1 in which they presented their prospective data on the influence of subclinical tumor spreading markers on survival after curative surgery for colorectal cancer. We appreciate their work and the idea of incorporating the detection of tumor cells in lymph nodes, peritoneal lavage fluid, and bone marrow as markers of local, locoregional, and distant spread.
Barreto SG, Shukla PJ. Demonstration of the Presence of Circulating Tumor Cells as Evidence of Metastatic Potential. Arch Surg. 2008;143(11):1134. doi:10.1001/archsurg.143.11.1134-a